Biopharmaceuticals and novel therapies
Mobilize the purpose-driven expertise of iBET to gain insightful, thorough development of your biotechnology products. With over 25 years experience, we offer a most comprehensive package of services in the area of Biopharmaceuticals and Novel Therapies.
Animal Cell Technology
- Cell line development
- Bioprocess development for recombinant proteins, mAbs, Vaccines, VLPs and Viral Vectors for Gene Therapy
- Bioprocessing of Stem cells for cell therapy and regenerative medicine applications
- Advanced cellular models for pre-clinical research
Discovery, Production and Characterization of Biopharmaceuticals
Production of Biologics
- Protein production in E. coli, yeast, mammalian & insect cells; stable or transient gene expression
- Strategy design including reverse translation, sequence optimization and vector construction
Proteomic Tools
- Limited proteolysis for protein construct design
- Protein stability and protein: ligand interaction studies (Surface Plasmon Ressonance)
- 3D protein structure determination (X-ray, NMR)
- Molecular modeling applied to protein structure and enzyme kinetics
- NMR spectroscopy for drug screening and hit optimization
- New targets and more efficient combinatorial therapies
Characterization & Quality Control
- Mass Spectrometry: Protein identification, peptide mass fingerprint, intact mass measurement, fragmentation profile
- Post translational modifications analysis
- N-terminal and peptide sequencing
- HPLC
- Host cell protein detection and identification
- For additional assays available at iBET's Analytical Services Unit GO HERE
BioChemical Engineering Tools
- Novel Tools for Extraction and Process Monitoring
- Modeling Downstream Processing: in Particular Porous Systems
- Systems Biology for Cell Culture and Process Development
- Systems Biology Applied to Bioseparation Processes
Drug Delivery
- Nano/Micro Encapsulation & Impregnation
- Release kinetics
- Formulation